Publications

2025

Hatzikotoulas K, Southam L, , […] Ullum H, Valdes AM,  van Heel DA, Walters RG,   Weir DR, [..]   van Meurs JBJ, Styrkarsdottir U, Zeggini E 2025: Translational genomics of osteoarthritis in 1,962,069 individuals. Nature. April 2025 DOI: 10.1038/s41586-025-08771-z  URL: https://www.nature.com/articles/s41586-025-08771-z

Gowler PRW, Arendt-Tranholm A, Turnbull J, Jha RR, Onion D, Kelly T, Kouraki A, Millns P, Gohir S, Franks S, Barrett DA, Valdes AM, Chapman V: Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience. 2025 Jan 21;28(2):111862. doi: 10.1016/j.isci.2025.111862. Feb 21.PMID: 39995860

Kirk D, Louca P, Attaye I, Zhang X, Wong KE, Michelotti GA, Falchi M, Valdes AM, Williams FMK, Menni C. Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome. Metabolites. 2025 Feb 12;15(2):121. doi: 10.3390/metabo15020121. PMID: 39997746

van de Streek M, Ali AT, El-Sayed Moustafa JS, Glastonbury CA, Spector TD, Valdes AM, Staff JF, Morton J, Hodgkinson A, Bell JT, Small KS. Quantification of heavy metal exposure in a British population cohort links total mercury levels in plasma with skin tissue-specific changes in mitochondrial-related gene expression. Sci Total Environ. 2025 Feb 1;963:178427. doi: 10.1016/j.scitotenv.2025.178427. Epub 2025 Jan 15.PMID: 3981815

2024

Zheng SL, Henry A, Cannie D, […] Valdes AM, van Setten J, van Vugt M, Veluchamy A, Verschuren WMM, Villard E, Yang Y; COVIDsortium; DBDS Genomic Consortium; Estonian Biobank Research Team; HERMES Consortium; et al.  Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. Nat Genet. 2024 Dec;56(12):2646-2658. doi: 10.1038/s41588-024-01952-y.  PMID: 39572783

Agosti P, Kouraki A, Dionisi T, Addolorato G, D'Innocenzo L, Sorrentino S, De Maio F, De Candia E, Blanco-Miguez A, Bazzani D, Bonadiman A, Tonidandel G, Bolzan M, Gianniello F, Passamonti SM, Abbattista M, Valdes AM, Bucciarelli P, Peyvandi F, Menni C. Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study.  Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2659-2661. doi: 10.1161/ATVBAHA.124.321490. PMID: 39479767

Vijay A, Kelly A, Miller S, Marshall M, Alonso A, Kouraki A, Probert C, Simpson EJ, Valdes AM. Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study. Nutrients. 2024 Sep 30;16(19):3326. doi: 10.3390/nu16193326. PMID: 39408292

Kouraki A, Vijay A, Gohir S, Millar B, Kelly A, Valdes AM. Physical Therapy for Knee Pain Relief Induces Changes in Gut Microbiome Composition: A Secondary Analysis of Data From a Randomized Controlled Trial. Sports Health. 2024 Oct 6:19417381241283812. doi: 10.1177/19417381241283812.  PMID: 39370648

Kouraki A, Zheng AS, Miller S, Kelly A, Ashraf W, Bazzani D, Bonadiman A, Tonidandel G, Bolzan M, Vijay A, Nightingale J, Menni C, Ollivere BJ, Valdes AM. Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience. 2024 Aug 22;27(9):110783. doi: 10.1016/j.isci.2024.110783. PMID: 39286492

Valdes AM, Louca P, Visconti A, Asnicar F, Bermingham K, Nogal A, Wong K, Michelotti GA, Wolf J, Segata N, Spector TD, Berry SE, Falchi M, Menni C. Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.  BMC Med. 2024 Aug 7;22(1):321. doi: 10.1186/s12916-024-03543-4. PMID: 39113058

O'Sullivan O, Stocks J, Schofield S, Bilzon J, Boos CJ, Bull AMJ, Fear NT, Watt FE, Bennett AN, Kluzek S, Valdes AM. Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population - Findings from the ADVANCE study. Osteoarthritis Cartilage. 2024 Dec;32(12):1636-1646. doi: 10.1016/j.joca.2024.07.016.  PMID: 39103080

Kouraki A, Nogal A, Nocun W, Louca P, Vijay A, Wong K, Michelotti GA, Menni C, Valdes AM. Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites. 2024 May 29;14(6):311. doi: 10.3390/metabo14060311. PMID: 38921446

Valdes AM, Ikram A, Taylor LA, Zheng A, Kouraki A, Kelly A, Ashraf W, Vijay A, Miller S, Nightingale J, Selby NM, Ollivere BJ. Preoperative inflammatory biomarkers reveal renal involvement in postsurgical mortality in hip fracture patients: an exploratory study. Front Immunol. 2024 Jun 10;15:1372079. doi: 10.3389/fimmu.2024.1372079. PMID: 38919625

Franks SJ, Gowler PRW, Dunster JL, Turnbull J, Gohir SA, Kelly A, Valdes AM, King JR, Barrett DA, Chapman V, Preston S. Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Math Biosci. 2024 Aug;374:109228. doi: 10.1016/j.mbs.2024.109228. PMID: 38851528

Bermingham KM, Linenberg I, Polidori L, Asnicar F, Arrè A, Wolf J, Badri F, Bernard H, Capdevila J, Bulsiewicz WJ, Gardner CD, Ordovas JM, Davies R, Hadjigeorgiou G, Hall WL, Delahanty LM, Valdes AM, Segata N, Spector TD, Berry SE. Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nat Med. 2024 Jul;30(7):1888-1897. doi: 10.1038/s41591-024-02951-6.  PMID: 38714898

Turnbull J, Jha RR, Gowler PRW, Ferrands-Bentley R, Kim DH, Barrett DA, Sarmanova A, Fernandes GS, Doherty M, Zhang W, Walsh DA, Valdes AM, Chapman V. Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.  Osteoarthritis Cartilage. 2024 Aug;32(8):990-1000. doi: 10.1016/j.joca.2024.04.006. PMID: 38648876

rrett DA, Valdes AM, Alderson J, Williams A, Vincent TL, Watt FE, Chapman V. The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms.  Am J Sports Med. 2024 Mar;52(4):987-997. doi: 10.1177/03635465241228209.  PMID: 38406872

Kirk D, Costeira R, Visconti A, Khan Mirzaei M, Deng L, Valdes AM, Menni C. Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Rep. 2024 Feb 27;43(2):113728. doi: 10.1016/j.celrep.2024.113728. PMID: 38300802

Abhishek A, Peckham N, Pade C, Gibbons JM, Cureton L, Francis A, Barber V, Williams JAE, Appelbe D, Eldridge L, Julier P, Altmann DM, Bluett J, Brooks T, Coates LC, Rombach I, Semper A, Otter A, Valdes AM, Nguyen-Van-Tam JS, Williams HC, Boyton RJ, McKnight Á, Cook JA; VROOM study investigators. Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. Lancet Rheumatol. 2024 Feb;6(2):e92-e104. doi: 10.1016/S2665-9913(23)00298-9. PMID: 38267107

2023

Ghosh T S, Valdes A M. Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease BMJ  2023; 383 :e075180 doi:10.1136/bmj-2023-075180

Kouraki A, Kelly A, Vijay A, [..], Valdes AM. Reproducible microbiome composition signatures of anxiety and depressive symptoms. Comput Struct Biotechnol J. 2023 Oct 18;21:5326-5336. doi: 10.1016/j.csbj.2023.10.035.

Ana Nogal, [..], Ana M. Valdes, Cristina Menni; A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Diabetes 1 December 2023; 72 (12): 1870–1880

Ana Nogal, Francesco Asnicar, Amrita Vijay, Afroditi Kouraki, [..], Ana M. Valdes & Cristina Menni (2023)Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation, Gut Microbes, 15:1, DOI: 10.1080/19490976.2023.2240050

Louca P, [..], Vijay A, Kouraki A, [..], Valdes AM, Menni C. The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery. Cell Rep Med. 2023 Apr 18;4(4):100993. doi: 10.1016/j.xcrm.2023.100993. Epub 2023 Apr 5

Mehta O, Vijay A, [..], Valdes AM. Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis - A Cross-Sectional Study. J Pain. 2023 Jul;24(7):1251-1261. doi: 10.1016/j.jpain.2023.02.023

Valdes, Ana Maria1. S-57-2: THE GUT MICROBIOME AND CARDIOVASCULAR RISK FACTORS IN HUMANS. Journal of Hypertension 41(Suppl 1):p e125, January 2023.  DOI: 10.1097/01.hjh.0000914024.63284.f8

2021

Wyatt, Patrick, [..], Valdes, Ana. (2021). Postprandial glycaemic dips predict appetite and energy intake in healthy individuals. Nature Metabolism. 3. 10.1038/s42255-021-00383-x.

Vijay, Amrita & Kouraki, Afroditi, [..], Valdes, Ana. (2021). The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids. Gut Microbes. 13. 10.1080/19490976.2021.1997559

Petrović, Tea, Vijay, Amrita, [..], Valdes, Ana, Hadzibegović, Irzal & Lauc, Gordan. (2022). IgG N-glycome changes during the course of severe COVID-19: An observational study. EBioMedicine. 81. 104101. 10.1016/j.ebiom.2022.104101

Al-Awadi, Amina, [..], Valdes, Ana, Vijay, Amrita, Bawden, Stephen, Gowland, Penny & Aithal, Guruprasad. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): a study protocol of an efficacy mechanism evaluation. BMJ open. 11. e045802. 10.1136/bmjopen-2020-045802.

Vijay, Amrita & Valdes, Ana. (2021). Role of the gut microbiome in chronic diseases: a narrative review. European Journal of Clinical Nutrition. 76. 1-13. 10.1038/s41430-021-00991-6.

Vijay, Amrita, Al-Awadi, Amina, [..], Aithal, Guruprasad. (2021). Dietary factors underlying non-alcoholic fatty liver disease (NAFLD) and its severity: a large, population-based, case-control study. Gut. 70. A4.2-A5. 10.1136/gutjnl-2021-BASL.8

Vijay, Amrita, Astbury, Stuart, [..], Valdes, Ana. (2021). Dietary Interventions Reduce Traditional and Novel Cardiovascular Risk Markers by Altering the Gut Microbiome and Their Metabolites. Frontiers in Cardiovascular Medicine. 8. 691564. 10.3389/fcvm.2021.691564

Mazidi, Mohsen, Valdes, Ana, [..]. (2021). Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants. The American Journal of Clinical Nutrition. 114. 10.1093/ajcn/nqab132.

Mehta, Ojasvi, [..], Vijay, Amrita. (2021). Gut Microbial Profile Is Associated With Residential Settings and Not Nutritional Status in Adults in Karnataka, India. Frontiers in Nutrition. 10.3389/fnut.2021.595756.

Merino, Jordi, [..], Valdes, Ana. (2021). Precision Nutrition and Reliability of Continuous Glucose Monitors: Insights From the PREDICT Study. Current Developments in Nutrition. 5. 513-513. 10.1093/cdn/nzab041_028